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Yan Zang Selected Research

ONX 0912

9/2014Carfilzomib and oprozomib synergize with histone deacetylase inhibitors in head and neck squamous cell carcinoma models of acquired resistance to proteasome inhibitors.
12/2012The next generation proteasome inhibitors carfilzomib and oprozomib activate prosurvival autophagy via induction of the unfolded protein response and ATF4.
10/2012Carfilzomib and ONX 0912 inhibit cell survival and tumor growth of head and neck cancer and their activities are enhanced by suppression of Mcl-1 or autophagy.

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Yan Zang Research Topics

Disease

11Neoplasms (Cancer)
04/2024 - 03/2008
8Squamous Cell Carcinoma of Head and Neck
07/2016 - 09/2008
6Burns
05/2009 - 10/2003
4Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse)
01/2017 - 07/2014
3Melanoma (Melanoma, Malignant)
01/2023 - 01/2021
2Carcinoma (Carcinomatosis)
04/2022 - 11/2008
2Weight Loss (Weight Reduction)
01/2020 - 01/2019
2Non-Hodgkin Lymphoma (Lymphosarcoma)
07/2016 - 02/2014
2Head and Neck Neoplasms (Head and Neck Cancer)
10/2012 - 11/2008
2Neoplasm Metastasis (Metastasis)
11/2008 - 03/2008
1Breast Neoplasms (Breast Cancer)
04/2024
1Hemolysis
11/2023
1Overweight
01/2023
1Hepatocellular Carcinoma (Hepatoma)
04/2022
1Papillary Thyroid Cancer
01/2022
1Stroke (Strokes)
02/2021
1Avitaminosis (Vitamin Deficiency)
01/2020
1Hypertension (High Blood Pressure)
01/2019
1Malnutrition (Nutritional Deficiencies)
01/2019
1Obesity
01/2019
1Mouth Neoplasms (Oral Cancer)
07/2016
1Human Influenza (Influenza)
01/2016
1Lymphoma (Lymphomas)
01/2016
1Carcinogenesis
02/2014
1Multiple Myeloma
12/2012
1Paralysis (Palsy)
11/2008
1Nasopharyngeal Carcinoma
11/2008
1Asphyxia (Suffocation)
11/2008
1Cerebral Infarction
11/2008
1Epistaxis (Nosebleed)
11/2008
1Hemorrhage
11/2008
1Infections
11/2008
1Nasopharyngeal Neoplasms (Cancer of the Nasopharynx)
11/2008
1Necrosis
11/2008
1Rupture
11/2008
1Thyroid Neoplasms (Thyroid Cancer)
11/2008
1Ulcer
11/2008
1Neurofibrosarcoma (MPNST)
03/2008

Drug/Important Bio-Agent (IBA)

5salicylhydroxamic acid (SHAM)IBA
05/2009 - 04/2004
4Proteins (Proteins, Gene)FDA Link
04/2022 - 05/2009
3DNA (Deoxyribonucleic Acid)IBA
04/2024 - 02/2014
3carfilzomibIBA
09/2014 - 10/2012
3ONX 0912IBA
09/2014 - 10/2012
3Proteasome InhibitorsIBA
09/2014 - 08/2009
3CytokinesIBA
03/2005 - 04/2004
2MicroRNAs (MicroRNA)IBA
04/2024 - 04/2022
2pembrolizumabIBA
01/2022 - 01/2021
2Interleukin-10 (Interleukin 10)IBA
01/2017 - 05/2009
2Type 4 Fibroblast Growth Factor ReceptorIBA
07/2016 - 02/2014
2interleukin-21 (interleukin 21)IBA
08/2014 - 07/2014
2Bortezomib (Velcade)FDA Link
12/2012 - 08/2009
2AntigensIBA
05/2009 - 10/2003
1Biomarkers (Surrogate Marker)IBA
04/2024
1PotassiumIBA
11/2023
1L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA
11/2023
1CarbonIBA
01/2023
1Immune Checkpoint InhibitorsIBA
01/2023
1Messenger RNA (mRNA)IBA
04/2022
1Arachidonate 5-Lipoxygenase (5 Lipoxygenase)IBA
04/2022
1cobimetinibIBA
01/2022
1Circular RNAIBA
01/2022
1VemurafenibIBA
01/2022
1RibonucleoproteinsIBA
01/2022
1RNA (Ribonucleic Acid)IBA
02/2021
1Vitamin B 12 (Cyanocobalamin)FDA LinkGeneric
01/2020
1LipidsIBA
01/2019
1AntibodiesIBA
01/2017
1CarcinogensIBA
07/2016
1sulforaphaneIBA
07/2016
14-Nitroquinoline-1-oxide (4 Nitroquinoline 1 oxide)IBA
07/2016
1Immunoglobulin G (IgG)IBA
01/2016
1Rituximab (Mabthera)FDA Link
01/2016
1Histone Deacetylase InhibitorsIBA
09/2014
1Chloroquine (Aralen)FDA LinkGeneric
02/2014
1obatoclaxIBA
02/2014
1Annexin A5IBA
02/2014
1pregna-4,17-diene-3,16-dione (guggulsterone)IBA
08/2009
1STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA
08/2009
1Interleukin-13IBA
05/2009
1Small Interfering RNA (siRNA)IBA
05/2009
1ABT-737IBA
05/2009
1Cisplatin (Platino)FDA LinkGeneric
05/2009
1Etoposide (VP 16)FDA LinkGeneric
05/2009
1Peptides (Polypeptides)IBA
05/2009
1Interleukin-2 (IL2)IBA
05/2009
1Nimodipine (Modus)FDA LinkGeneric
11/2008
1Therapeutic UsesIBA
09/2008

Therapy/Procedure

3Therapeutics
01/2023 - 03/2008
3Drug Therapy (Chemotherapy)
01/2016 - 05/2009
2Bariatric Surgery
01/2020 - 01/2019
2Radiotherapy
11/2008 - 03/2008
1Toothbrushing
02/2021
1Immunotherapy
01/2021
1Oral Administration
10/2012
1Aftercare (After-Treatment)
11/2008
1Emergency Treatment
11/2008
1First Aid (Aids, First)
11/2008
1Ligation
11/2008
1Myocutaneous Flap
11/2008
1Neck Dissection (Radical Neck Dissection)
09/2008